mutation class

Gene Rearrangement

synonyms

t(11;14)

t(11;14)(q13;q32)

Rituximab With or Without Stem Cell Transplant in Treating Patients With Minimal Residual Disease-Negative Mantle Cell Lymphoma in First Complete Remission

198 sites for NCT03267433

CCND1 Expression, +4 more biomarkers

Mantle Cell Lymphoma

autologous hematopoietic stem cell transplantation, +2 more drugs

cellular therapy, +2 more types

A Study of Venetoclax and Dexamethasone Compared With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma

157 sites for NCT03539744

IGH-CCND1 Fusion, +1 more biomarker

Multiple Myeloma

dexamethasone, +1 more drug

chemotherapy, +1 more type

Study of Capivasertib in Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

20 sites for NCT05008055

CCND1 Overexpression, +2 more biomarkers

Grade 1 Follicular Lymphoma, +4 more conditions

capivasertib

targeted therapy

A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma

279 sites for NCT04115631

CCND1 Expression, +2 more biomarkers

Mantle Cell Lymphoma

acalabrutinib, +3 more drugs

chemotherapy, +2 more types

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

15 sites for NCT04728893

CCND1 Overexpression, +2 more biomarkers

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, +5 more conditions

nemtabrutinib

targeted therapy

Study of Venetoclax in Combination With Carfilzomib and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma (MM)

29 sites for NCT02899052

IGH-CCND1 Fusion, +1 more biomarker

Multiple Myeloma

carfilzomib, +2 more drugs

chemotherapy, +2 more types

dexamethasone + venetoclax

IGH-CCND1 Fusion, +1 more biomarker

Multiple Myeloma

Relapse

Subsequent line

dexamethasone, +1 more drug

chemotherapy, +1 more type

venetoclax +/- dexamethasone

IGH-CCND1 Fusion, +1 more biomarker

AL Amyloidosis

Relapse/refractory

Subsequent line

dexamethasone, +1 more drug

chemotherapy, +1 more type