TMB-High | Cancer Search

Details 28 Trials 27 Therapies

mutation class

Genomic Signature

synonyms

TMB

TMB +

TMB high

Hypermutant

Hyper-mutant

Hypermutated

Hypermutation

hyper-mutation

hyper-mutatant

High Mutation Load

high mutation burden

high mutational load

hypermutator phenotype

high mutational burden

tumor mutational burden

high tumor mutation burden

Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

104 sites for NCT04589845

AKT1 Mutation, +39 more biomarkers

Malignant Solid Tumor

ado-trastuzumab emtansine, +8 more drugs

immunotherapy, +1 more type

A Study to Evaluate Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)

155 sites for NCT03178552

ALK Alternative Transcription Site, +7 more biomarkers

Non-Small Cell Lung Carcinoma

alectinib, +2 more drugs

immunotherapy, +1 more type

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

78 sites for NCT02693535

AKT1 Mutation, +128 more biomarkers

Adenocarcinoma of the Gastroesophageal Junction, +19 more conditions

abemaciclib, +23 more drugs

immunotherapy, +1 more type

Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

25 sites for NCT02628067

Deficient DNA Mismatch Repair (dMMR), +6 more biomarkers

Anal Squamous Cell Carcinoma, +18 more conditions

pembrolizumab

immunotherapy

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioblastoma With Elevated Mutational Burden

264 sites for NCT04145115

TMB-High

Glioblastoma

ipilimumab, +1 more drug

immunotherapy

A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response

48 sites for NCT04632992

AKT1 Mutation, +17 more biomarkers

Malignant Solid Tumor

ado-trastuzumab emtansine, +11 more drugs

chemotherapy, +2 more types

Show 28 Trials for TMB-High

pembrolizumab

TMB-High

Malignant Solid Tumor