T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

~10 mi. (Ephrata, Pennsylvania, +576 more cities)

Ephrata Cancer Center

ERBB2 Amplification, +1 more biomarker

Breast Carcinoma

ado-trastuzumab emtansine, +1 more drug

targeted therapy

Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

~10 mi. (Ephrata, Pennsylvania, +744 more cities)

Ephrata Cancer Center, +1 more facility

Breast Carcinoma

axillary lymph node dissection, +1 more drug

radiation therapy, +1 more type

Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

~10 mi. (Ephrata, Pennsylvania, +664 more cities)

Ephrata Community Hospital, +1 more facility

PD-L1 High Expression (TPS >= 1%), +1 more biomarker

Non-Small Cell Lung Carcinoma

carboplatin, +2 more drugs

chemotherapy, +1 more type

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

~10 mi. (Ephrata, Pennsylvania, +825 more cities)

Ephrata Cancer Center

AKT1 Mutation, +91 more biomarkers

Breast Carcinoma, +3 more conditions

adavosertib, +26 more drugs

immunotherapy, +1 more type

Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer

~10 mi. (Ephrata, Pennsylvania, +240 more cities)

Ephrata Cancer Center

Endometrial Adenocarcinoma, +5 more conditions

carboplatin, +2 more drugs

chemotherapy, +1 more type

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

~10 mi. (Ephrata, Pennsylvania, +656 more cities)

Ephrata Cancer Center

Deficient DNA Mismatch Repair (dMMR), +8 more biomarkers

Colon Adenocarcinoma, +1 more condition

atezolizumab, +3 more drugs

chemotherapy, +1 more type

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

~10 mi. (Ephrata, Pennsylvania, +533 more cities)

Ephrata Cancer Center

ERBB2 Amplification, +1 more biomarker

Invasive Breast Carcinoma

ado-trastuzumab emtansine, +6 more drugs

chemotherapy, +2 more types

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

~10 mi. (Ephrata, Pennsylvania, +235 more cities)

Ephrata Cancer Center

Prostate Adenocarcinoma

abiraterone, +9 more drugs

hormone therapy, +2 more types

De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

~10 mi. (Ephrata, Pennsylvania, +255 more cities)

Ephrata Cancer Center

CDKN2A Overexpression, +1 more biomarker

Oropharyngeal Squamous Cell Carcinoma

nivolumab, +1 more drug

immunotherapy, +1 more type

Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

~10 mi. (Ephrata, Pennsylvania, +822 more cities)

Ephrata Cancer Center

ER Negative, +2 more biomarkers

Invasive Breast Carcinoma

carboplatin, +3 more drugs

chemotherapy

Testing The Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

~10 mi. (Ephrata, Pennsylvania, +556 more cities)

Ephrata Cancer Center

CD19 Expression, +2 more biomarkers

Chronic Lymphocytic Leukemia

ibrutinib, +2 more drugs

chemotherapy, +2 more types

Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

~10 mi. (Ephrata, Pennsylvania, +954 more cities)

Ephrata Cancer Center

Non-Small Cell Lung Carcinoma

crizotinib, +4 more drugs

chemotherapy, +2 more types