Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

~9 mi. (Altoona, Pennsylvania, +664 more cities)

UPMC Altoona

PD-L1 High Expression (TPS >= 1%), +1 more biomarker

Non-Small Cell Lung Carcinoma

carboplatin, +2 more drugs

chemotherapy, +1 more type

De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

~9 mi. (Altoona, Pennsylvania, +255 more cities)

UPMC Altoona

CDKN2A Overexpression, +1 more biomarker

Oropharyngeal Squamous Cell Carcinoma

nivolumab, +1 more drug

immunotherapy, +1 more type

Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer

~9 mi. (Altoona, Pennsylvania, +469 more cities)

UPMC Altoona

Non-Small Cell Lung Carcinoma

carboplatin, +6 more drugs

chemotherapy, +2 more types

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

~9 mi. (Altoona, Pennsylvania, +224 more cities)

UPMC Altoona

HPV Negative

Hypopharyngeal Carcinoma, +3 more conditions

atezolizumab, +4 more drugs

chemotherapy, +3 more types

Testing the Addition of the Drugs, Apalutamide and Abiraterone Acetate With Prednisone, to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer

~9 mi. (Altoona, Pennsylvania, +142 more cities)

UPMC Altoona

Prostate Adenocarcinoma

apalutamide, +2 more drugs

hormone therapy, +1 more type

Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer

~9 mi. (Altoona, Pennsylvania, +225 more cities)

UPMC Altoona

Bladder Urothelial Carcinoma

atezolizumab, +5 more drugs

chemotherapy, +2 more types

A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

~25 mi. (Huntingdon, Pennsylvania, +356 more cities)

UPMC Arnold Palmer-Norwin

HER2 Positive

Invasive Breast Carcinoma

fam-trastuzumab deruxtecan

targeted therapy

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

~37 mi. (State College, Pennsylvania, +533 more cities)

Geisinger Medical Group

ERBB2 Amplification, +1 more biomarker

Invasive Breast Carcinoma

ado-trastuzumab emtansine, +6 more drugs

chemotherapy, +2 more types

S0820, Adenoma and Second Primary Prevention Trial

~37 mi. (State College, Pennsylvania, +616 more cities)

Geisinger Medical Group

Colon Carcinoma, +1 more condition

eflornithine, +2 more drugs

chemotherapy, +1 more type

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

~37 mi. (State College, Pennsylvania, +413 more cities)

Geisinger Medical Group

BRAF Mutation

Melanoma

ipilimumab, +2 more drugs

immunotherapy, +1 more type

Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

~37 mi. (State College, Pennsylvania, +822 more cities)

Geisinger Medical Group, +1 more facility

ER Negative, +2 more biomarkers

Invasive Breast Carcinoma

carboplatin, +3 more drugs

chemotherapy

Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

~37 mi. (State College, Pennsylvania, +954 more cities)

Geisinger Medical Group

Non-Small Cell Lung Carcinoma

crizotinib, +4 more drugs

chemotherapy, +2 more types