A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

~4 mi. (Manchester, United Kingdom, +356 more cities)

The Christie Hospital

HER2 Positive

Invasive Breast Carcinoma

fam-trastuzumab deruxtecan

targeted therapy

Circulating Tumour DNA guidEd Therapy for Stage IIB/C mElanoma After surgiCal resecTION

~4 mi. (Manchester, United Kingdom)

The Christie NHS Foundation Trust

BRAF V600E, +6 more biomarkers

Cutaneous Melanoma

nivolumab, +1 more drug

immunotherapy

Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving FOLFOXIRI/Bevacizumab for Metastatic Colorectal Cancer (mCRC):

~4 mi. (Manchester, United Kingdom, +97 more cities)

The Christie

Microsatellite Stable (MSS)

Colorectal Adenocarcinoma

bevacizumab, +2 more drugs

chemotherapy, +1 more type

A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors

~4 mi. (Manchester, United Kingdom, +56 more cities)

The Christie NHS Foundation Trust

Adenocarcinoma of the Gastroesophageal Junction, +8 more conditions

ladiratuzumab vedotin

chemotherapy, +1 more type

An Open Label Study Evaluating the Efficacy and Safety of Etrumadenant (AB928) Based Treatment Combinations in Participants With Metastatic Colorectal Cancer.

~4 mi. (Manchester, United Kingdom, +52 more cities)

Investigational Site

Colorectal Adenocarcinoma

AB680, +4 more drugs

chemotherapy, +2 more types

Trimodality Therapy With/Out Durvalumab to Treat Patients With Muscle-Invasive Bladder Cancer

~4 mi. (Manchester, United Kingdom, +21 more cities)

The Christie NHS Foundation Trust

Bladder Urothelial Carcinoma

durvalumab

immunotherapy

CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Desmoplastic Small Round Cell Tumor

~4 mi. (Manchester, United Kingdom, +53 more cities)

The Christie

Desmoplastic Small Round Cell Tumor

cyclophosphamide, +2 more drugs

chemotherapy, +1 more type

A Study of Brentuximab Vedotin and CHP in Frontline Treatment of PTCL With Less Than 10% CD30 Expression

~4 mi. (Manchester, United Kingdom, +31 more cities)

Christie Hospital NHS Foundation Trust

TNFRSF8 Deficient Expression

Adult T-Cell Leukemia/Lymphoma, +8 more conditions

brentuximab vedotin, +3 more drugs

chemotherapy, +2 more types

A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)

~4 mi. (Manchester, United Kingdom, +34 more cities)

Manchester Royal Infirmary Hospital

CD19 Expression

B-Cell Acute Lymphoblastic Leukemia

AUTO1

cellular therapy, +1 more type

A Study of BMS-986253 in Combination With Nivolumab or Nivolumab Plus Ipilimumab in Advanced Cancers

~4 mi. (Manchester, United Kingdom, +47 more cities)

Local Institution

Malignant Solid Tumor

HuMax-IL8, +2 more drugs

immunotherapy

Study of ASTX029 in Subjects With Advanced Solid Tumors

~4 mi. (Manchester, United Kingdom, +14 more cities)

The Christie NHS Foundation Trust

ARAF Mutation, +16 more biomarkers

Malignant Solid Tumor

ASTX029

targeted therapy

A Study of TAS-120 in Patients With Metastatic Breast Cancer

~4 mi. (Manchester, United Kingdom, +22 more cities)

The Christie NHS Foundation Trust

ER Negative, +6 more biomarkers

Breast Carcinoma

fulvestrant, +1 more drug

hormone therapy, +1 more type