T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

~7 mi. (Gettysburg, Pennsylvania, +576 more cities)

Adams Cancer Center

ERBB2 Amplification, +1 more biomarker

Breast Carcinoma

ado-trastuzumab emtansine, +1 more drug

targeted therapy

Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

~7 mi. (Gettysburg, Pennsylvania, +744 more cities)

Adams Cancer Center

Breast Carcinoma

axillary lymph node dissection, +1 more drug

radiation therapy, +1 more type

Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

~7 mi. (Gettysburg, Pennsylvania, +664 more cities)

Adams Cancer Center

PD-L1 High Expression (TPS >= 1%), +1 more biomarker

Non-Small Cell Lung Carcinoma

carboplatin, +2 more drugs

chemotherapy, +1 more type

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

~7 mi. (Gettysburg, Pennsylvania, +825 more cities)

Adams Cancer Center

AKT1 Mutation, +91 more biomarkers

Breast Carcinoma, +3 more conditions

adavosertib, +26 more drugs

immunotherapy, +1 more type

Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer

~7 mi. (Gettysburg, Pennsylvania, +240 more cities)

Adams Cancer Center

Endometrial Adenocarcinoma, +5 more conditions

carboplatin, +2 more drugs

chemotherapy, +1 more type

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

~7 mi. (Gettysburg, Pennsylvania, +656 more cities)

Adams Cancer Center

Deficient DNA Mismatch Repair (dMMR), +8 more biomarkers

Colon Adenocarcinoma, +1 more condition

atezolizumab, +3 more drugs

chemotherapy, +1 more type

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

~7 mi. (Gettysburg, Pennsylvania, +533 more cities)

Adams Cancer Center

ERBB2 Amplification, +1 more biomarker

Invasive Breast Carcinoma

ado-trastuzumab emtansine, +6 more drugs

chemotherapy, +2 more types

Stereotactic Body Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients With Stage IIA-B Prostate Cancer

~7 mi. (Gettysburg, Pennsylvania, +234 more cities)

Adams Cancer Center

Prostate Adenocarcinoma

stereotactic body radiation therapy

radiation therapy, +1 more type

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

~7 mi. (Gettysburg, Pennsylvania, +235 more cities)

Adams Cancer Center

Prostate Adenocarcinoma

abiraterone, +9 more drugs

hormone therapy, +2 more types

De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

~7 mi. (Gettysburg, Pennsylvania, +255 more cities)

Adams Cancer Center

CDKN2A Overexpression, +1 more biomarker

Oropharyngeal Squamous Cell Carcinoma

nivolumab, +1 more drug

immunotherapy, +1 more type

A Study of Debio 1143 (Xevinapant) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)

~7 mi. (Gettysburg, Pennsylvania, +220 more cities)

Gettysburg Cancer Center

HPV Negative

Hypopharyngeal Squamous Cell Carcinoma, +2 more conditions

cisplatin, +2 more drugs

chemotherapy, +2 more types

Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

~7 mi. (Gettysburg, Pennsylvania, +822 more cities)

Adams Cancer Center

ER Negative, +2 more biomarkers

Invasive Breast Carcinoma

carboplatin, +3 more drugs

chemotherapy