T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

~6 mi. (Santa Cruz, California, +576 more cities)

Palo Alto Medical Foundation-Santa Cruz

ERBB2 Amplification, +1 more biomarker

Breast Carcinoma

ado-trastuzumab emtansine, +1 more drug

targeted therapy

Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

~6 mi. (Santa Cruz, California, +744 more cities)

Dominican Santa Cruz Hospital, +1 more facility

Breast Carcinoma

axillary lymph node dissection, +1 more drug

radiation therapy, +1 more type

Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

~6 mi. (Santa Cruz, California, +664 more cities)

Palo Alto Medical Foundation-Santa Cruz

PD-L1 High Expression (TPS >= 1%), +1 more biomarker

Non-Small Cell Lung Carcinoma

carboplatin, +2 more drugs

chemotherapy, +1 more type

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

~6 mi. (Santa Cruz, California, +825 more cities)

Palo Alto Medical Foundation-Santa Cruz

AKT1 Mutation, +91 more biomarkers

Breast Carcinoma, +3 more conditions

adavosertib, +26 more drugs

immunotherapy, +1 more type

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

~6 mi. (Santa Cruz, California, +656 more cities)

Palo Alto Medical Foundation-Santa Cruz

Deficient DNA Mismatch Repair (dMMR), +8 more biomarkers

Colon Adenocarcinoma, +1 more condition

atezolizumab, +3 more drugs

chemotherapy, +1 more type

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

~6 mi. (Santa Cruz, California, +533 more cities)

Palo Alto Medical Foundation-Santa Cruz

ERBB2 Amplification, +1 more biomarker

Invasive Breast Carcinoma

ado-trastuzumab emtansine, +6 more drugs

chemotherapy, +2 more types

S0820, Adenoma and Second Primary Prevention Trial

~6 mi. (Santa Cruz, California, +616 more cities)

Palo Alto Medical Foundation-Santa Cruz

Colon Carcinoma, +1 more condition

eflornithine, +2 more drugs

chemotherapy, +1 more type

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

~6 mi. (Santa Cruz, California, +606 more cities)

Palo Alto Medical Foundation-Santa Cruz

CD274 Amplification

Angiosarcoma, +26 more conditions

ipilimumab, +1 more drug

immunotherapy

Testing the Drug Atezolizumab or Placebo With Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer

~6 mi. (Santa Cruz, California, +497 more cities)

Palo Alto Medical Foundation-Santa Cruz

HER2 Positive

Breast Adenocarcinoma

atezolizumab, +4 more drugs

chemotherapy, +2 more types

Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer

~6 mi. (Santa Cruz, California, +469 more cities)

Palo Alto Medical Foundation-Santa Cruz

Non-Small Cell Lung Carcinoma

carboplatin, +6 more drugs

chemotherapy, +2 more types

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

~6 mi. (Santa Cruz, California, +413 more cities)

Palo Alto Medical Foundation-Santa Cruz

BRAF Mutation

Melanoma

ipilimumab, +2 more drugs

immunotherapy, +1 more type

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

~6 mi. (Santa Cruz, California, +77 more cities)

Sutter Palo Alto Medical Foundation: Santa Cruz, +1 more facility

AKT1 Mutation, +128 more biomarkers

Adenocarcinoma of the Gastroesophageal Junction, +19 more conditions

abemaciclib, +23 more drugs

immunotherapy, +1 more type