Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

~13 mi. (Oak Ridge, Tennessee, +656 more cities)

Thompson Oncology Group-Oak Ridge

Deficient DNA Mismatch Repair (dMMR), +8 more biomarkers

Colon Adenocarcinoma, +1 more condition

atezolizumab, +3 more drugs

chemotherapy, +1 more type

Testing the Drug Atezolizumab or Placebo With Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer

~13 mi. (Oak Ridge, Tennessee, +497 more cities)

Thompson Oncology Group-Oak Ridge

HER2 Positive

Breast Adenocarcinoma

atezolizumab, +4 more drugs

chemotherapy, +2 more types

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

~13 mi. (Oak Ridge, Tennessee, +413 more cities)

Thompson Oncology Group-Oak Ridge

BRAF Mutation

Melanoma

ipilimumab, +2 more drugs

immunotherapy, +1 more type

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

~21 mi. (Knoxville, Tennessee, +144 more cities)

University of Tennessee Medical Center Knoxville ( Site 0019)

Clear Cell Renal Cell Carcinoma

belzutifan, +3 more drugs

immunotherapy, +1 more type

Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

~21 mi. (Knoxville, Tennessee, +89 more cities)

University of Tennessee Medical Center ( Site 0039)

ER Positive, +2 more biomarkers

Breast Carcinoma

capecitabine, +4 more drugs

chemotherapy, +1 more type

Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

~21 mi. (Knoxville, Tennessee, +744 more cities)

University of Tennessee - Knoxville

Breast Carcinoma

axillary lymph node dissection, +1 more drug

radiation therapy, +1 more type

Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

~21 mi. (Knoxville, Tennessee, +454 more cities)

East Tennessee Childrens Hospital

Classical Hodgkin Lymphoma

brentuximab vedotin, +7 more drugs

chemotherapy, +3 more types

A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

~21 mi. (Knoxville, Tennessee, +173 more cities)

East Tennessee Childrens Hospital

B-Cell Lymphoblastic Leukemia/Lymphoma

asparaginase Erwinia chrysanthemi, +12 more drugs

chemotherapy, +2 more types

Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)

~21 mi. (Knoxville, Tennessee, +93 more cities)

The University of Tennessee Medical Center ( Site 0034)

Bladder Carcinoma, +1 more condition

cisplatin, +4 more drugs

chemotherapy, +3 more types

Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment

~21 mi. (Knoxville, Tennessee, +199 more cities)

Research Site

Hepatocellular Carcinoma

bevacizumab, +2 more drugs

immunotherapy, +1 more type

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy

~21 mi. (Knoxville, Tennessee, +260 more cities)

Thompson Cancer Survival Center

ERBB2 Amplification, +1 more biomarker

Invasive Breast Carcinoma

ado-trastuzumab emtansine, +1 more drug

immunotherapy, +1 more type

Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)

~21 mi. (Knoxville, Tennessee, +122 more cities)

The University of Tennessee Medical Center ( Site 0116)

Small Cell Lung Carcinoma

etoposide, +5 more drugs

chemotherapy, +3 more types