TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

~8 mi. (Grand Blanc, Michigan, +77 more cities)

Genesys Hurley Cancer Institute

AKT1 Mutation, +128 more biomarkers

Adenocarcinoma of the Gastroesophageal Junction, +19 more conditions

abemaciclib, +23 more drugs

immunotherapy, +1 more type

Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

~15 mi. (Flint, Michigan, +523 more cities)

Hurley Medical Center, +3 more facilities

Clear Cell Renal Cell Carcinoma

cabozantinib, +2 more drugs

immunotherapy, +1 more type

T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

~15 mi. (Flint, Michigan, +576 more cities)

Hurley Medical Center, +3 more facilities

ERBB2 Amplification, +1 more biomarker

Breast Carcinoma

ado-trastuzumab emtansine, +1 more drug

targeted therapy

Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

~15 mi. (Flint, Michigan, +744 more cities)

Genesee Hematology Oncology PC, +3 more facilities

Breast Carcinoma

axillary lymph node dissection, +1 more drug

radiation therapy, +1 more type

A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy

~15 mi. (Flint, Michigan, +233 more cities)

Genesee Hematology Oncology PC, +3 more facilities

Prostate Adenocarcinoma

degarelix, +4 more drugs

hormone therapy, +1 more type

Trying to Find the Correct Length of Treatment With Immune Checkpoint Therapy

~15 mi. (Flint, Michigan, +244 more cities)

Genesee Hematology Oncology PC, +3 more facilities

Bladder Urothelial Carcinoma, +4 more conditions

atezolizumab, +4 more drugs

immunotherapy

Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

~15 mi. (Flint, Michigan, +664 more cities)

Genesee Hematology Oncology PC, +3 more facilities

PD-L1 High Expression (TPS >= 1%), +1 more biomarker

Non-Small Cell Lung Carcinoma

carboplatin, +2 more drugs

chemotherapy, +1 more type

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

~15 mi. (Flint, Michigan, +825 more cities)

Genesys Hurley Cancer Institute, +3 more facilities

AKT1 Mutation, +91 more biomarkers

Breast Carcinoma, +3 more conditions

adavosertib, +26 more drugs

immunotherapy, +1 more type

Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer

~15 mi. (Flint, Michigan, +240 more cities)

Genesee Cancer and Blood Disease Treatment Center, +2 more facilities

Endometrial Adenocarcinoma, +5 more conditions

carboplatin, +2 more drugs

chemotherapy, +1 more type

Testing the Addition of Ixazomib to Lenalidomide in Patients With Evidence of Residual Multiple Myeloma, OPTIMUM Trial

~15 mi. (Flint, Michigan, +143 more cities)

Genesys Hurley Cancer Institute, +2 more facilities

Multiple Myeloma

ixazomib, +1 more drug

chemotherapy, +1 more type

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

~15 mi. (Flint, Michigan, +327 more cities)

Genesee Hematology Oncology PC, +3 more facilities

Multiple Myeloma

bortezomib, +3 more drugs

chemotherapy, +3 more types

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

~15 mi. (Flint, Michigan, +656 more cities)

Genesee Cancer and Blood Disease Treatment Center, +3 more facilities

Deficient DNA Mismatch Repair (dMMR), +8 more biomarkers

Colon Adenocarcinoma, +1 more condition

atezolizumab, +3 more drugs

chemotherapy, +1 more type