A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)

~20 mi. (Poway, California, +262 more cities)

California Cancer Associates for Research & Excellence, Inc.

ER Positive, +1 more biomarker

Breast Adenocarcinoma

giredestrant, +2 more drugs

hormone therapy, +1 more type

A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer

~29 mi. (La Mesa, California, +60 more cities)

Sharp Memorial Hospital

Prostate Adenocarcinoma

abiraterone, +4 more drugs

hormone therapy

Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

~32 mi. (San Marcos, California, +523 more cities)

Kaiser Permanente-San Marcos

Clear Cell Renal Cell Carcinoma

cabozantinib, +2 more drugs

immunotherapy, +1 more type

Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

~32 mi. (San Marcos, California, +454 more cities)

Kaiser Permanente-San Marcos

Classical Hodgkin Lymphoma

brentuximab vedotin, +7 more drugs

chemotherapy, +3 more types

A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

~32 mi. (San Marcos, California, +356 more cities)

Kaiser Permanente

HER2 Positive

Invasive Breast Carcinoma

fam-trastuzumab deruxtecan

targeted therapy

Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

~32 mi. (San Marcos, California, +664 more cities)

Kaiser Permanente-San Marcos

PD-L1 High Expression (TPS >= 1%), +1 more biomarker

Non-Small Cell Lung Carcinoma

carboplatin, +2 more drugs

chemotherapy, +1 more type

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

~32 mi. (San Marcos, California, +825 more cities)

Kaiser Permanente-San Marcos

AKT1 Mutation, +91 more biomarkers

Breast Carcinoma, +3 more conditions

adavosertib, +26 more drugs

immunotherapy, +1 more type

Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer

~32 mi. (San Marcos, California, +240 more cities)

Kaiser Permanente-San Marcos

Endometrial Adenocarcinoma, +5 more conditions

carboplatin, +2 more drugs

chemotherapy, +1 more type

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

~32 mi. (San Marcos, California, +656 more cities)

Kaiser Permanente-San Marcos

Deficient DNA Mismatch Repair (dMMR), +8 more biomarkers

Colon Adenocarcinoma, +1 more condition

atezolizumab, +3 more drugs

chemotherapy, +1 more type

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

~32 mi. (San Marcos, California, +606 more cities)

Kaiser Permanente-San Marcos

CD274 Amplification

Angiosarcoma, +26 more conditions

ipilimumab, +1 more drug

immunotherapy

Testing the Drug Atezolizumab or Placebo With Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer

~32 mi. (San Marcos, California, +497 more cities)

Kaiser Permanente-San Marcos

HER2 Positive

Breast Adenocarcinoma

atezolizumab, +4 more drugs

chemotherapy, +2 more types

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

~32 mi. (San Marcos, California, +413 more cities)

Kaiser Permanente-San Marcos

BRAF Mutation

Melanoma

ipilimumab, +2 more drugs

immunotherapy, +1 more type