Trial Details 81 Total Sites

Efficacy and Safety of Olaparib (MK-7339) With or Without Bevacizumab Compared to Bevacizumab With a Fluoropyrimidine in Unresectable or Metastatic Colorectal Cancer (CRC) (MK-7339-003/LYNK-003)

This is an efficacy and safety study of olaparib alone or in combination with bevacizumab being compared to bevacizumab with a fluoropyrimidine in participants with unresectable or metastatic colorectal cancer who have not progressed following first-line induction. The primary hypotheses are: Olaparib + Bevacizumab is superior to a fluoropyrimidine + Bevacizumab with respect to progression-free survival (PFS) using Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST 1.1) as assessed by blinded independent central review (BICR); Olaparib is superior to a fluoropyrimidine + Bevacizumab with respect to PFS using RECIST 1.1 as assessed by BICR.

phase

Phase 3

status

Recruiting

enrollment

525

score

51

start date

2020-08-19

last updated

2022-01-12

biomarkers

N/A

Chicago, Illinois
facility
University of Chicago ( Site 1357)
1 facility
Recruiting
Portland, Oregon
facility
Providence Portland Medical Center ( Site 1400)
facility
Oregon Health & Science University ( Site 1411)
2 facilities
Recruiting
Nashville, Tennessee
facility
Vanderbilt University Medical Center ( Site 1362)
1 facility
Recruiting
New Orleans, Louisiana
facility
University Medical Center New Orleans ( Site 1365)
1 facility
Recruiting
St. Louis, Missouri
facility
Washington University in St. Louis ( Site 1384)
1 facility
Recruiting
Pittsburgh, Pennsylvania
facility
Allegheny Singer Research Institute ( Site 1364)
1 facility
Recruiting
Lincoln, Nebraska
facility
Cancer Partners of Nebraska ( Site 1353)
1 facility
Recruiting
Louisville, Kentucky
facility
James Graham Brown Cancer Center ( Site 1393)
1 facility
Recruiting
Grand Rapids, Michigan
facility
Cancer & Hematology Centers of Western Michigan ( Site 1358)
1 facility
Recruiting
Fort Collins, Colorado
facility
Poudre Valley Health System ( Site 1402)
1 facility
Recruiting
Fullerton, California
facility
St Joseph Heritage Healthcare-Oncology ( Site 1383)
1 facility
Recruiting
Athens, Georgia
facility
University Cancer & Blood Center, LLC ( Site 1381)
1 facility
Recruiting